J.Jpn. Surg. Soc.. 90(1): 59-63, 1989

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Original article

WOUND HEALING, BLOOD COAGULATION AND FIBRINOLYSIS DURING OPERATIONS INVOLVING GASTRIC CANCER SURGERY

Serial changes of FPA, FPBβ15-42, FN, XIIIa, and α₂PI were investigated for the study on wound healing, blood coagulation, and fibrinolysis during gastric cancer surgery. For a control, we compared the preoperative values with the postoperative ones. These results also were compared with the values in healthy volunteers and in patients with cholelithiasis or myoma uteri. Our findings were as follows;
1) Compared with the control values, a statistically significant elevation of FPA, FPBβ15-42 and FPA/FPBβ15-42 ratios in patients with gastric cancer was noticed after operation.
2) Compared with the control values, a statistically marked decrease of FN, XIIIa and α2PI in patients with gastric cancer was observed after operation.
3) The preoperative FPA and FPBβ15-42 levels of gastric cancer patients were appreciably greater than those of normal healthy volunteers. Compared with patients with cholelithiasis or myoma uteri, however, the only preopeative FPA of gastric cancer patients showed significantly high levels.
4) FN and α2PI revealed a notable positive correlation. These results suggest (1) increase of coagulation activity (thrombin formation) in gastric cancer patients; (2) increase of intravascular coagulation and fibrinolytic activity (thrombin and plasmin formation) during gastric cancer surgery; and, (3) depression of FN, XIIIa and α2PI during surgery was due to sequestration at the site of tissue injury.

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