J.Jpn. Surg. Soc.. 90(1): 49-58, 1989
Original article
PROMOTING EFFECT OF BILE ACIDS ON GASTRIC CARCINOGENESIS INDUCED BY MNNG IN RATS
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First Department of Surgery, Tottori University School of Medicine, Yonago, Japan Masataka Takebayashi |
At the first experiment, two hundred and fifteen male Wistar rats were divided into 5 groups; after oral administration MNNG (120μg/ml) for 24 weeks, group 1 receieved tap water, group 2 administered of chenodeoxycholic acid (CDCA) solution, group 3 had deoxycholic acid (DCA) solution for the next 12 weeks. Group 4 received CDCA solution and group 5 received DCA solution for 36 weeks without MNNG. At the second experiment, fifty one rats were divided into 3 groups; for the first 12 weeks, group 1 received tap water, group 2 CDCA and group 3 DCA. These 3 groups received MNNG for the next 24 weeks followed by tap water for 12 weeks.
The incidence of gastric adenocarcinoma in MNNG-treated rats was significantly higher in group 3 (63.6%) as compared with that in group 1 (36.7%) in the first experiment. No carcinoma lesions was found in groups 4 and 5. In the second experiment, no significant changes was observed among 3 groups. Undifferentiated adenocarcinomas were identified in groups 2 and 3, especially treated with MNNG plus bile acids.
The result suggested a promoting effect of bile acids, especially DCA, in stomach carcinogenesis.
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