[
Abstract]
[
Full Text PDF] （in Japanese / 2517KB）
[Members Only And Two Factor Auth.] J.Jpn. Surg. Soc.. 89(9): 1524-1527, 1988
Report on the annual meeting
EXTENDED TREATMENT FOR GASTRIC CANCER PATIENTS WITH PERITONEAL SEEDING
Fourteen patients with far-advanced gastric cancer were treated surgically followed by intraperitoneal hyperthermic perfusion (IPHP) with mitomycin C (MMC) and misonidazole (MIS), a thermosensitizing drug. Immediately after extensive resection of the abdominal tumors, a 2-hour IPHP was performed at the inflow temperature 47.4±0.5℃ and at the outflow temperature 45.3±0.5℃, using equipment designed for treatment of cancerous peritoneal seeding, as a closed circuit, and under hypothermic general anesthesia at 31.2±0.5℃. In 6 of the 14 patients, cancersous ascites was absent after IPHP. Repeated cytogic examination of the lavage from pelvic cul-de-sac were neagative, in all cases. The postoperative courses were uneventful except for 2 patients, in whom slight leakage occurred. All patients were discharged, and 4 in the 14 patients died of recurrence in the liver, abdominal and/or pleural cavities 8.8±2.1 months after IPHP. The remaining 10 are in good health 12.1±3.1months after IPHP. Transient hepatic dysfunction and hypoproteinemia occurred post-hyperthermically in all cases. This extensive surgery combined with IPHP using MMC and MIS was well tolerated and is a safe anti-tumor treatment for gastric cancer with peritoneal dissemination. Neurotoxicity due to MIS was nil.
To read the PDF file you will need Adobe Reader installed on your computer.