J.Jpn. Surg. Soc.. 89(7): 1114-1121, 1988

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Original article

A NEW PROCEDURE FOR PREVENTION OF MNMS USING PLASMAFILTER

In order to prevent myonephropathic metabolic syndrome (MNMS) following acute arterial occlusion of the extremities, the efficacy of plasmafiltration to eliminate myoglobin which causes acute renal failure and other metabolites was evaluated by experimental model.
Twenty five mongrel dogs weighing 10 to 20kg were used. Infra-renal aorta and unilateral femoral arteries were ligated and 2/3 of the femoral muscle was carved. After 24 hrs, these ligations were released and thrombectomy was carried out.
The dogs were devided into two groups : Group 1 was consisted of the dogs without any treatment and group 2 dogs were treated by plasmafiltration.
The changes in serum myoglobin, potassium, lactic acid and etc. were compared between the two groups.
The plasmafilter was hollow-fiber type that was made of polypropylene fiber.
The serum level of myoglobin, potassium, CPK, GOT and BUN tended to decrease remarkably after revascularization in group 2 in contrast with those in group 1. There were statistically significant differences between the corresponding data of the two groups. Although the lactic acid levels were lower in group 2 than group 1, those were not significant statistically.
In conclusion, the applicaton of plasmafilter was effective for the treatment of hyperkalemia and removal of myoglobin and unknown moderate molecular weight pathogenic substances to prevent MNMS.

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