J.Jpn. Surg. Soc.. 89(3): 381-387, 1988

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Original article

CHANGES IN THE LEVELS OF LIPID PEROXIDES IN REGENERATING RAT LIVER AND THE EFFECT OF PRETREATMENT WITH CoQ₁₀

The present study was undertaken to determine whether CoQ₁₀ pretreatment could modify cellular free radical metabolism in regenerating rat liver and enhance hepatic DNA synthesis. Male Wistar rats (250－300g) were used. Partial 70％ hepatectomy was performed according to Higgins and Anderson. CoQ₁₀ (6mg/kg body weight) and its solvent as a placebo were injected intravenously 1 hour before operation. Twenty-four hours or 48 hours after 70％ hepatectomy resulted in 55％ or 50％ decreases of hepatic ATP, and marked decreases of endogenous CoQ homologs (CoQ₉ and CoQ₁₀) , α-tocopherol and reduced glutathione (GSH) in remnant liver and was accompanied by 2.5-fold increases in lipid peroxides. However, in CoQ₁₀-treated animals synthesis of ATP was accelerated after 48 hours after partial hepatectomy. There were no changes in the levels of CoQ₉, α-tocopherol, or GSH or in the level of the enhanced CoQ₁₀ in regenerating liver. The pretreatment also completely suppressed the elevation of lipid peroxide. Moreover, CoQ₁₀ administration markedly increased hepatic DNA synthesis at 48 hours after partial hepatectomy. These results indicate that cellular damage during hepatic regeneration is in part due to lipid peroxidation, and suggest that CoQ₁₀ is effective in the pretreatment of liver resection.

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