J.Jpn. Surg. Soc.. 89(2): 162-172, 1988
Original article
HISTOCHEMICAL STUDY OF ADENOCARCINOMATOUS COMPONENTS IN CARCINOMA OF THE ESOPHAGUS
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The Second Department of Surgery, Faculty of Medicine, The University of Tokyo, Tokyo, Japan Ken-ichi Mafune |
Mucus-histochemistry, especially mucicarmine staining, revealed mucus-secreting components in 48 lesions (35.6%). This is a much higher rate of esophageal cancers with adenocarcinomatous components than previously reported. Furthermore, no significant clinicopathologic differences were noted between the mucus-stain-positive and-negative groups, except for a higher rate of venous infiltration in the mucus-stain-positive group. Carcinoma of the esophagus with adenocarcinomatous components, particu- larly mucoepidermoid carcinoma, has generally been considered to arise from the proper esophageal gland or its ductal epithelium. However, certain evidence in this study, such as the mucus-secreting components in mucosal carcinoma and a high incidence of intraepithelial spread, suggested a squamous epithelium origin.
Immuno-histochemistry using the peroxidase-antiperoxydase (PAP) technique revealed 49 lesions (36.3%) to be positive for tumor carcinoembryonic antigen (CEA). Tissue CEA was found mostly around mucins and/or glandular structures, and CEA-stain-positive lesions were more prominent in the mucus- stain-positive group, suggesting that CEA in carcinoma of the esophagus originates in the adenocar-cinomatous components. Furthermore, the mucus-stain-positive group showed significantly higher rate of patients with pathologic serum CEA levels. Therefore, the serum CEA level is useful for the follow-up patients with mucus-stain-positive carcinoma of the esophagus.
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