J.Jpn. Surg. Soc.. 88(9): 1279-1282, 1987
Report on the annual meeting
A NEW MATERIAL ENHANCING WOUND HEALING, “G・T・XIII”
―BASIC STUDIES AND CLINICAL APPLICATIONS―
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Dept. of Surgery, Osaka National Hospital, Osaka, Japan Akio Sugitachi, Ryuichi Hayashi, Yuichi Takatsuka, Nario Kitani, Tsutomu Kawahara |
Basic studies confirmed that topical accumulation of an insoluble fibrin clot on the G・T・XIII was remarkable. Activity of factor XIII in the material was stable for more than 20 months. Tearing-force of wound on the rat muscles where G・T・XIII had been implanted was significantly high, comparing with that for other materials. G・T・XIII was also applied as hemostatic for hepatic biopsy in rats. The duration for a complete hemostasis in the hepatic biopsy was within 90 seconds for G・T・XIII, while that for the controls was over 450 seconds. Histological studies showed that the material was well adapted with the tissues and evidence of rejection was not observed.
G・T・XIII was then clinically applied as wound dressing for patients with skin defects due to burn, leg ulcer, necrosis after skin transplantation and postoperative lymphorrhoea. Wound healing was promoted with favorable result in each case.
The clinical potentials of G・T・XIII include use as a wound dressing, as a hemostatic agent, as a thrombotic agent for transcatheter arterial embolization, in sclerotherapy for varices, and so on.
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