J.Jpn. Surg. Soc.. 88(9): 1272-1275, 1987
Report on the annual meeting
THE SIGNIFICANCE OF THE SUBMUCOSAL LAYER FROM THE VIEW-POINT OF THE HEALING PROCESS OF THE INCISED WOUND ON CANINE STOMACH WALL
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Department of Surgery I, Shinshu University School of Medicine, Matsumoto, Japan Hideyuki Ichikawa, Shiro Hayashi |
The concentration of hydroxyproline indicated the highest value in the submucosal tissue among layers of canine stomach wall.
At an early stage of the healing process after the wounding on the anterior wall of canine stomach, the concentrations of hexosamine and hyaluronic acid were increased both in the mucosa, including the submucosal layer, and in the muscle layer of the stomach wall at the portion of incised wound.
A significant decrease in the tissue concentration of hydroxyproline was indicated more evidently in the submucosal layer than other two layers of the stomach wall on the third wounding day.
Evident increase of hydroxyproline on the 7th day after the wounding both in the mucosa and the muscle layer suggested a more active response in the submucosal layer after wounding.
The highest tissue concentration of antibiotics (ceftizoxime), after i.v. injection, was indicated both in the submucosal layer of non-wounding stomach and the wounded stomach wall on the third day after wounding.
These findings might suggest that the submucosal layer would play the most important part in the healing process at the anastomotic site of the gastrointestinal tract.
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