J.Jpn. Surg. Soc.. 88(9): 1247-1250, 1987

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Report on the annual meeting

DELAYING FACTORS OF WOUND HEALING ON OBSTRUCTIVE JAUNDICE MODEL AND THEIR TREATMENT

Inducing obstructive jaundice, we investigated the difference of the wound healing of gastric incisions with controls and the efficacy of a fibrin adhesive to the wound healing in rats, and reported the results of clinical application of the fibrin adhesive. Using male Wistar rats weighing 300g, the obstructive jaundiced models were induced by ligation and division of the common bile duct. Investigations were performed on 2, 3, 5, 9 and 14 days after the ligation, that is, 1) a measurement of blood flow volumes surrounding the wound, 2) a measurement of bursting strength at the suture site, 3) observation of histochemical changes of the wound, and 4) laboratory examinations of total bilirubin, GOT, GPT, PT, PTT and fibrinogen. The results showed the delayed wound healing in jaundiced groups. The causes were thought to be a delayed inflammatory process in the early phase of wound healing and impairment of fibrin network. The application of fibrin adhesive promoted the wound healing in spite of jaundiced state and the usefulness of fibrin adhesive was also demonstrated clinically.

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