J.Jpn. Surg. Soc.. 88(9): 1239-1242, 1987

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Report on the annual meeting

A BASIC STUDY OF THE EFFECT OF THE BASEMENT MEMBRANE MATRIX ON TISSUE REPAIR OR ON REGENERATION

Fetal tissue, i.e., the lung, pancreas and liver, were cultured on the sterile pig skin as a substrate. Long term culture of epithelium in each tissue was well done, except type I pneumocyte of lung, acinar cell of pancreas and hepatocytes. Most of the cultured cells has the same ultrastructure as shown in vivo. Functionally, the synthesis of enzymes or proteins characterized in each cell was capable to be detected mostly paralleled to that in vivo.
The modulation of hepatocytes was ascertained during culture.
Paradoxical change between fibronectin and laminin was observed in the regenerative liver or pancreas after partial resection.
The significance of the basement membrane matrix on the epithelisation, proliferation and differentiation was suggested.

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