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Abstract]
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[Members Only And Two Factor Auth.] J.Jpn. Surg. Soc.. 88(9): 1205-1208, 1987
Report on the annual meeting
BASIC MECHANISM OF MULTIPLE ORGAN FAILURE (MOF) AND THE PRINCIPLE OF ITS TREATMENT
Fifty cases of MOF were studied in relation to the changes in KBR (blood ketone body ratio : Acetoacetate/β-hydroxybutyrate) which reflects hepatic mitochondrial redox potential. Changes in KBR were classified into 4 groups : A (＞0.7), B (0.7－0.4), C (0.4－0.25), D (＜0.25). In the stage of Group A, no organ failure was seen. In Group B (10 cases), one or two organ failures were observed, although no patients died of them. In Group C (26 cases), however, 3 to 6 organ failures were observed and resulted in the increase in mortality rate (23 cases, 88％). In Group D (14 cases), mortality rate was 100％ with 4－7 organ failures. The decrease in the KBR is strongly linked with an occurrence of MOF. It was suggested that the derangement of hepatic mitochondrial function is associated with a precipitation of MOF by inducing metabolic abnormalities of the whole body. Therefore, the treatment of MOF should be directed toward an elevation of the decreased KBR beside an individual support of the failured organs.
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