J.Jpn. Surg. Soc.. 88(9): 1200-1204, 1987
Report on the annual meeting
SEPTIC SHOCK FOLLOWED BY MULTIPLE SYSTEMIC ORGAN FAILURE
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The First Department of Surgery, Fukui Medical School, Fukui, Japan Hiroshi Shimada, Akira Matsuba, Kohmei Seki, Noriaki Isobe, Yasuhiko Kojima, Hideharu Fujita, Gizo Nakagawara |
Compared with that in mild group, in the shock and DIC groups the high rate of endotoxemia and gramnegative bacteremia, and leukocytosis, the decreases of platelets counts, s-albumin, CH50, C3, C3a, phagocytic K value measured by CsFe loading and plasma fibronectin were remarkable.
The decreases of CH50 and C3 in the DIC group was more remarkable than those in the shock group.
Compared with high complement dogs or normal complement dogs, in the low complement Schwartzman dog DIC was easily produce, showing remarkable decrease of leukocyte counts and 6-keto-PGF1α after LPS injection.
It was concluded the aggravation of sepsis was produced on the condition that the hypercoagulative state could not be resolved ; there was due to hypophagocytic function resulting from the decrease of opsonic proteins, and the disturbance of inhibiting function of PGI2 on platelets aggregations.
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