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Abstract]
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[Members Only And Two Factor Auth.] J.Jpn. Surg. Soc.. 88(9): 1192-1195, 1987
Report on the annual meeting
CLINICAL ANALYSIS OF EARLY COLLOID ADMINISTRATION IN BURN SHOCK ; EFFECTS OF FRESH FROZEN PLASMA ON HEMODYNAMICS
Hemodynamic effects of colloid administration in early postburn period were studied in 31 burned patients with burns ranging 30－96％ (average 63.3％) BSA. Fluid resuscitation was started with lactated Ringer’s solution ; the amount was adjusted so as to maintain systolic pressure above 100mmHg and urine output of 20－40ml/hr・m
2. After 6 to 18 hours postburn, fresh frozen plasma was added in the amount of 0.056±0.022ml /hr・kg・％burn, partially replacing lactated Ringer’s solution but without increase in the total amount of fluid given per hour. Hemodynamic parameters were monitored using Swan-Ganz catheter, Plasma infusion induced an increase in cardiac index ; from 2.19±0.60 before plasma infusion to 3.16±0.92 l/min・m
2 2 hours after plasma infusion (p＜0.01). Also, left ventricular stroke work index increased and systemic vascular resistance decreased at 2 hours. In 17 patients the increase in left ventricular stroke work index was not accompanied with an increase in pulmonary wedge pressure, suggesting that myocardial performance improved by the plasma infusion. The results indicate that fresh frozen plasma administration at 6－18 hours postburn restores cardiac output, which is partly attributable to the improvement in cardiac function.
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