J.Jpn. Surg. Soc.. 88(9): 1144-1148, 1987

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Report on the annual meeting

FUNCTIONAL ASPECTS OF THYROID SURGERYーMALIGNANT NEOPLASMS

TSH-dependency of differentiated carcinoma of the thyroid gland was studied in vitro. TSH receptors were demonstrated in all cases. Adenylate cyclase activity was heterogeneous from case to case, some of them showed very high activity. Desensitization could not be observed in some patients, in whom adenylate cyclase activity did not drop after the incubation with TSH. These findings further support the existence of TSH dependency in some cases of differentiated carcinoma of the thyroid.
Serum TSH was measured after the administration of TRH using high-sensitivity TSH kit (IRMA) in order to assess the appropriate amount of thyroid hormone to suppress endogenous TSH. It was found that at least 3μg/kg body weight of 1-thyroxine was necessary.
In 36 patients with medullary thyroid carcinoma, calcitonin (CT), CEA, and other peptides in tissue were studied histochemically by PAP method. CGRP and GRP were demonstrated in many patients. Changes in serum levels of CT and CEA were beneficial in predicting the prognosis of medullary thyroid carcinoma.

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