J.Jpn. Surg. Soc.. 88(9): 1113-1116, 1987

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Report on the annual meeting

ESTROGEN RECEPTOR (ER), ESTRADIOL (E₂) AND EPIDERMAL GROWTH FACTOR (EGF) IN THE GASTRIC CANCER AS BIOLOGICAL MARKERS OF PROLIFERATION AND PROGRESSION

The diffuse type or undifferentiated cancer of the stomach is predominant in younger patients, and is particularly more prevalent in female patients. Thus, there is a possibility that this type of cancer is influenced by hormonal factors, particularly female hormones.
In this study the presence of receptor for estrogen (ER) by the method of McGuire, and the localization of intracellular E₂ and EGF by the method of Su-ming Hsu in gastric cancer are reported. ER was present in 14 (21%) of 66 male patients and 12 (26%) of 46 female patients. ER positive cases were characterized grossly as Borrmann type 4, and microscopically as diffuse type with scirrhous growth pattern. E₂ and EGF were located in the cytoplasm of the cancer cells and fibroblast in the stroma. Positive cases of E₂ was not found in early gastric cancer, but was found in 53 (37%) of 142 advanced cases. EGF was positive in 15% of early cases, and in 55% of advanced cases. E₂ and EGF positive cases were characterized as advanced cases, and scirrhous growth. The findings suggest that hormonal and growth factors are involved in gastric cancer and that the cancer contains endocrinic characteristics.

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