[
Abstract]
[
Full Text PDF] （in Japanese / 2327KB）
[Members Only And Two Factor Auth.] J.Jpn. Surg. Soc.. 88(9): 1100-1104, 1987
Report on the annual meeting
ANALYSIS OF THE IMMUNOSUPPRESSIVE MECHANISMS IN CANCER PATIENTS AND THE APPLICATION OF THE PROCEDURE TO REGULATE THEM FOR CANCER THERAPY
To develop the immunotherapy in cancer therapy, the immunosuppressive mechanisms were analysed and the procedure to regulate them was applied for cancer therapy in cancer patients. It was demonstrated that factors inhibiting lymphocyte proliferative responses and inducing suppressor cells existed in cancer sera and that lymphocyte surface receptors against serum inhibitory factors increased with tumor progress. On the other hand, suppressor T cells, suppressor precursors and suppressor inducer T cells (OKT4
+2H4
+ cells) were found to exist predominantly in the spleen, suggesting that spleen may contribute to the immunosuppression. A suggestive prolongation of survival rate was observed in patients who underwent total gastrectomy combined with splenectomy as compared with those without splenectomy. Adoptive immunotherapy with lymphokine activated killer cells in combinatin with plasma exchange was performed in the advanced cancer patients. Of 13 patients evaluated, 4 patients (30.8%) developed partial response and 1 (7.7%) minor response. These results suggest that the immunosuppressive mechanisms are predominant in cancer patients and that the regulation of them are required for the development of cancer immunotherapy.
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