J.Jpn. Surg. Soc.. 88(9): 1097-1099, 1987

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Report on the annual meeting

SIGNIFICANCE OF MITOCHONDRIAL ANALYSIS IN LIVER SURGERY

We have reported for several years that the functional reserve of the liver can be determined by the hepatocellular energy status which is inevitably affected by hepatic mitochondrial functions, namely, oxidative phosphorylative activity. Hepatic mitochondrial activity can be estimated by the mitochondrial redox state (NAD/NADH), and reflected as the ratio of acetoacetate and β-hydroxybutyrate. Clinically, the mitochondrial redox state can be detected by measurement of the blood ketone body ratio, because ketone bodies freely penetrate the mitochondrial membrane and the cellular membrane and appear in the blood. Evidence has accumulated to indicate that the blood ketone body ratio is an adequate and convenient parameter by which both acute and prolonged changes of the hepatic function can be estimated.

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