J.Jpn. Surg. Soc.. 88(9): 1093-1096, 1987

---

Report on the annual meeting

MALIGNANCY OF HEPATOCELLULAR CARCINOMA EVALUATED BY CLNICOPATHOLOGICAL FEATURES AND LONG-TERM SURVIVAL

Malignancy of hepatocellular carcinoma (HCC) was clinicopathologically evaluated in a view of postoperative survival. The survival rate was determined by Kaplan-Meier's method. The tumor growth rate was expressed as tumor doubling time calculated from preoperative alfa-fetoprotein values with over two measurements by plotting semilogarithmic paper. The survival rate was most affected by tumor invasion into portal vein and intrahepatic metastasis, as indicated followingly ; 3 and 5 year survival rates for VpO and Vp1 ; 61%, 57% and 38% ; －%, respectively. No cases with Vp2 or Vp3 could survive over 3 years. Histological tumor invasion into portal vein was noted in 53% of HCC cases withtumor size smaller than 3cm in diameter, 65% for capsular invasin and 45% for intrahepatic metastasis. Also, in cases with recurrence, histological portal tumor invasion, capsular invasion and intrahepatic metastasis were observed in 77%, 85% and 85%, respectively. The tumor growth rate was not concerned with vascular invasion, intrahepatic metastasis, tumor recurrence or its time. However, the doubling time was shorter at the time of tumor reccurrence than the preoperative. The tumor cell anaplasia affected the survival time, as indicated by no deaths in Edmondson grade 1 cases and 27% of 3 year survival rate for grade 3-4 cases. It is concluded that vascular invasion is one of most characterestic pathological features showing malignancy grade in hepatocellular carcinoma.

---

---

To read the PDF file you will need Adobe Reader installed on your computer.