J.Jpn. Surg. Soc.. 88(9): 1079-1083, 1987
Report on the annual meeting
STRATEGY AGAINST ESOPHAGEAL CANCERS ON THE BASIS OF CELLULAR BIOLOGICAL CHARACTERISTICS
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The Second Department of Surgery, Tohoku University School of Medicine, Sendai, Japan Tetsuro Nishihira, Takashi Akaishi, Ryuzaburo Shineha, Yoshihito Sekine, Kazunori Sanekata, Junji Sagawa, Shozo Mori |
1) Sialic acid, sialidase, sialyltransferase : The content of sialic acid was correlated to the activity of sialyltransferase, but was in opposition to sialidase activity. One patient with node positive superficial cancer and a high level of activity of sialyltransferase developed multiple node and liver metastasis.
2) Glutathione S-transferase-π (GST-π) : The content of GST-π in cancer cells is the most abundant among normal esophageal epithelial cells, displastic cells and cancer cells. Moreover, cells with rich GST-π show greater resistance to anticancer agents than those with poor GST-π.
3) DNA histogram: The two-year survival rate of diploid tumors is 92.3% and that of non-diploid tumors is 49.4%. The DNA index of tumors with skip lesions is shown to be over 1.5, and such cases wereall non-diploidy.
4) Expression of EGFR of cancer cells : EGF content was detected with 125I-hEGF binding assay. EGF binding capacity (fmol/mg protein) is the highest on metastatic nodes and higher on primary lesions of cancer than on normal esophageal mucosa.
5) Subtypes of tumor infiltrating lymphocytes (TIL) : The majority of infiltrating cells around the tumor tissues analysed with monoclonal antibodies were demonstrated to be T-cells. However, Helper/Inducer and/or Killer/Suppressor cells were equally detected.
6) Aggressive chemotherapy after curative operation of cancer of the esophagus with distant node metastasis : The five-year survival rate of the ten patients undergoing the above treatment was 30%, higher than that of all other types of therapies.
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