J.Jpn. Surg. Soc.
ISSN 1880-1129

[Abstract] [Full Text PDF] （in Japanese / 1878KB） [Members Only And Two Factor Auth.]

J.Jpn. Surg. Soc.. 88(9): 1075-1078, 1987

Report on the annual meeting

MALIGNANCY INDEX OF BREAST CANCER BASED ON FLOW CYTOMETRY AND HISTOLOGY

Department of Surgery, School of Medicine, Keio University, Tokyo, Japan
*) Laboratory of Biostatistics and Bioinformation Science, School of Medicine, Keio University

Kohji Enomoto, Osahiko Abe, Akihiko Nakamura, Kiyoshi Fujiwara, Shoichi Oka, Hideki Teramoto, Sunao Adachi*)

On the assumption that malignancy index of tumor is defined by its ability of proliferation, relation of the five parameters, D.N.A. Index, fraction of cell in the S phase, nuclear grade, degree of infiltration and size of tumor to prognosis was investigated.
Twenty five patients with breast cancer were included in the discriminant analysis. Eighteen patients were free of recurrence, seven patients had recurrence in 2 years. Rates of correlation of each variable were 0.62 with nuclear grade, 0.34 with fraction of cell in the S phase, 0.28 with size of tumor, 0.16 with D.N.A. Index. It was nuclear grade that had the most close relation with prognosis. Posterior probability obtained by discriminant analysis yielded 88% accurary, 100% specificity, and 57% sensitivity of high risk.
A malignancy index of tumor as well as mode of spreading of tumor should be taken into consideration at the time of making design of treatment for breast cancer.

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