J.Jpn. Surg. Soc.. 88(9): 1071-1074, 1987

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Report on the annual meeting

DIAGNOSIS AND TREATMENT FROM THE POINT OF VIEW OF THE BIOLOGICAL CHARACTERISTICS OF LUNG CANCER

The pathohistological findings of lung cancer are more varied than cancer of many other organs and this is reflected in its biological behaviour. Not only does prognosis vary between the various histologic types, it can also vary remarkably among the various subtypes of a given histologic type. The prognosis of poorly differentiated adenocarcinoma is much worse than that of well differentiated adenocarcinoma, as is that of giant cell carcinoma compared to other large cell carcinoma subtypes. Resection can be indicated in some cases of small cell carcinoma with prominent or minor large cell component but other subtypes of small cell carcinoma show extremely rapid and numerous distant metastasis, therefore contraindicating surgery as a therapeutic option.
In addition the sialic acid content value of malignant tissue increases as the degree of differentiation decreases and with the advance of the disease. It has also been clearly demonstrated that there is a relationship between the DNA ploidy and the degree of malignancy.
The various types of research concerning the biological degree of malignancy of lung cancer have little clinical significance of the results are not useful for multidisciplinary treatment. Therefore this type of research must be reexamined so that they can be performed as preoperative evaluative procedures.

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