J.Jpn. Surg. Soc.
ISSN 1880-1129

[Abstract] [Full Text PDF] （in Japanese / 1441KB） [Members Only And Two Factor Auth.]

J.Jpn. Surg. Soc.. 88(7): 885-893, 1987

Original article

MITRAL VALVULAR DISEASE AND ATRIAL NATRIURETIC POLYPEPTIDE

Department of Thoracic Surgery, School of Medicine, Nagoya University, Nagoya, Japan
*) The Research Institute of Environmental Medicine, Nagoya University, Nagoya, Japan

Yuzuru Amano, Toshio Abe, Nobuo Matsui*)

We compared plasma ANP concentration and atrial content of ANP as well as plasma concentrations of other fluid regurating hormones and renal function between the MVR group (n＝12) and the non MVR group (n＝14) during open heart surgery. Preoperatively there was no significant difference inplasma ADH and ACTH between two groups, however plasma ANP was significantly higher in the MVR group (96.9±16.2pg/ml) than in the non MVR group (22.8±8.6pg/ml) (p＜0.01). During extracorporeal circulation ANP was at a low level because of aortic clamping.
Tissue concentration of ANP in right appendages was higher (p＜0.02) in the MVR group (61.8±11.8nmol/g wet weight) (n＝6) than that in the non MVR group (14.9±3.1nmol/g wel weight) (n＝15). Also, concentration in left appendages of the MVR group (50.0±10.4nmol/g wet weight) (n＝4) was higher than that in right appendages of the non MVR group (p＜0.05). From these results it may be concluded that increased secretion of ANP is elicited by left atrial load and probably playing an important role on circulating blood volume regulation.

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