J.Jpn. Surg. Soc.. 88(6): 663-674, 1987

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Original article

EXPERIMENTAL STUDIES ON THERMOTOLERANCE IN HYPERTHERMIA TREATMENT FOR CANCER

Thermotolerance was investigated in hyperthermia using FM3A cells in vitro and in vivo. FM3A cells were heated at 42.0℃, 43.0℃ and 44.0℃ and the survival rate of the cells was decreased in this order. In in vitro experiments, thermotolerance induced by heating at 43.0℃ for 30 min reached at maximum, when the heating interval was 12 hr and thermotolerance induced by heating at 44.0℃ for 30 min reached at maximum, when the heating interval was 12 to 24 hr. In in vivo experiments, thermotolerance induced by heating at 42.0℃, 43.0℃ and 44.0℃ continued for 48 hr after initial heating and disappeared after 96 hr. In the repeated hyperthermia experiments, 7 times with 24 hr interval heating or 4 times with 48 hr interval heating did not show the significant inhibition of tumor growth as compared with the control group at 42.0℃, 43.0℃ and 44.0℃. However, twice with 96 hr interval heating indicated the significant inhibition of tumor growth at 42.0℃, 43.0℃ and 44.0℃. From these results it is suggested that hyperthermia treatment should be repeated after the disappearance of thermotolerance.

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