J.Jpn. Surg. Soc.. 88(4): 378-389, 1987

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Original article

COMPARISON OF WOUND HEALING OF INTESTINAL ANASTOMOSIS BY STAPLING DEVICES AND BY GAMBEE’S SUTURE UNDER NORMAL AND ABNORMAL CONDITIONS IN DOG

We investigated the wound healing of canine colon anastomosis by stapling devices (EEA and Nakayama's curved shaft device) comparing with that by Gambee's suture with special reference to vascularity of staple line, local blood flow, endoscopical findings, pathological findings and fluorescein viability test under normal and abnormal conditions.
Development of vascular network and communication at the sotare lines by stapler using a silicon rubber injection observed on the following days after operation. The local blood flow at the anastomosis measured by hydrogen gas clearance method increased gradually after operation. Endoscopic examination showed mucosal agglutination at the suture line by staplers was delayed compared to that of Gambee' s suture.
Under normal condition, the vascular communication of suture line by Gambee's was observed on the 5th post operative day, whereas it was observed on the 7th day by Staplers. Stainless steel staples were considered to be less reactive to the tissue than the other suture materials.
Under abnormal condition, wound healing was delayed because of the prolonged inflammation and edema. No remarkable difference was observed between manual anastomosis (Gambee) and stapled anastomosis under abnormal condition.

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