J.Jpn. Surg. Soc.. 87(9): 1005-1008, 1986

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Report on the annual meeting

TARGETTING THERAPY AND BIOMATERIALS

Targetting therapy is one of the most potent subject in medical science for the future. Typical targetting therapy is the so-called missile anti-cancer drug which will specificially attack the cancer cells with its missle warhead of monoclonal antibody. However, the word “targetting” might be interpreted in a broad sense here.
By using the advanced biomaterials as a drug career, the sophisticated design of drug delivery system is achievable. Authors developed the monolithic type of slow releasing system of anti-cancer drug with a hydrophobic synthetic polymers prepared by radiation-induced polymerization of which effectiveness was proved in animal experiment and clinical test. Moreover, authors are developing the drug-polyurethane composite releasing the drug at the controlIed rate which can be used as a antithrombogenic catheter inserted into blood vessels for a long period.
In the further progressed stage, the drug releasing rate can be controlled by such a stimulation as high concentration of biochemical products, magnetism, temperature and so on. The drug delivery system provided with sensor function and responsiveness to stimulation will realize “Homeostat” which is the ideal type of precise therapeutic system.

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