J.Jpn. Surg. Soc.
ISSN 1880-1129

[Abstract] [Full Text PDF] （in Japanese / 2244KB） [Members Only And Two Factor Auth.]

J.Jpn. Surg. Soc.. 87(9): 988-991, 1986

Report on the annual meeting

LASER APPLICATIONS IN SURGERY : PHOTODYNAMIC DIAGNOSIS AND THERAPY OF LUNG CANCER

*) Department of Surgery, Tokyo Medical College, Tokyo, Japan
**) Hamamatsu photonics, Hamamatsu, Japan

Harubumi Kato*), Chimori Konaka*), Shinya Otomo*), Hiroshi Iwabuchi*), Tetsuya Okunaka*), Yoshihiro Hayata*), Toru Hirano**)

Photodynamic diagnosis and therapy by means of a tumoriphilic photosensitizer and low energy laser photoradiation are described in this paper. Hematoporphyrin derivative (HpD) was used as a photosensitizer in these studies. In previous studies a krypton ion laser was used to excite the HpD and the fluorescence of the HpD taken up by cancer lesions was observed by an image intensifier, 73 lesions out of 78 lung cancer lesions showing fluorescence. There was a problem concerning interference from autofluorescence from the normal tissue using previous technology. The authors therefore developed a new diagnostic system using the excimer dye laser.
An argon dye laser was used in the treatment of cancer lesions. HpD was administered intravenously 72 hours prior to the photodynamic therapy. A total of 151 lesions in 127 cases of lung cancer were treated by photodynamic therapy. Thirty early stage lung cancer cases were included in this study. The age distribution was from 36 to 82 years old. Complete remission was observed in early stage cases but only palliative effects in advanced cases. The combination of this modality with surgical intervention was also suggested.

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