J.Jpn. Surg. Soc.. 87(6): 659-670, 1986

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Original article

THE INFLUENCE OF BILIARY DIVERSION ON CANINE GASTRIC ACID SECRETION AND GUT HORMONES

The effect of biliary reconstruction on gastric acid secretion and gut hormones was studied. Canine models undergoing either surgical biliary diversion or jejunal exclusion were compared and the following results were obtained.
1) The acid output from Heidenhain pouch after test meal loading remained in the same levels in the cholecystoduodenostomy (CD) group, the Thiry-Vella’s fistula (TVF) group and the cholecysto jejunostomy (CJ) group compared to the control group, while it decreased in the cholecystoileostomy group.
2) The integrated gastrin response after test meal loading decreased in the CI group. The integrated total GLI response remained unchanged in the CD group and CJ group, but markedly elevated in the TVF group and CI group. The integrated GIP response decreased in the TVF group and no response was obtained in the CI group. The integrated GI response was almost the same in all groups.
In conclusion, gut hormone secretion was found to be affected by jejunal exclusion and most strongly influenced by biliary diversion into the ileum. The present study also suggested that enteroglucagon had enterogastrone effect and that compensating mechanism existed among various gut hormones.

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