J.Jpn. Surg. Soc.. 86(10): 1405-1416, 1985

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Original article

EXPERIMENTAL AND CLINICAL STUDIES ON THE SIGNIFICANCE OF HUMAN T CELLS BEARING IgG-Fc RECEPTOR (TγCELLS) IN GASTRIC CANCER PATIENTS

In gastric cancer patients the proliferative response of Tγcells to phytohemagglutinin and Pokeweed mitogen was depressed, while that to Concanavalin-A was maintained as compared with that in Tnon-γ cells. Tγcells were activated by Concanavalin-A to suppress the proliferative response of responder cells. Furthermore, Tγcells from gastric cancer patients contained the suppressor cells which had been already activated in-vivo. On the other hand, natural cell mediated cytotoxic activities of Tγcells were greater than those of Tnon-γcells. Thus, it is likely that Tγcells consisted of the heterogenic populations, containing the suppressor and cytotoxic cells, and that suppressor cells were present dominantly in cancer patients. Furthermore, suppressor cells belonged to the distinct OKT8 positive fractions. Significant increase of Tγcells in cancer patients was observed and the proportion of Tγcells was positively correlated with advance of the disease. As for the tissue distribution, Tγcells were present dominantly in the spleen and scantly in the lymph nodes, however, the increase of Tγcells was observed in the lymph nodes with metastasis. The increase of IgG-Fc receptors on T cells and the induction of suppressor cells were observed simultaneously by co-culture with cancer sera.

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