J.Jpn. Surg. Soc.. 86(9): 1223-1226, 1985

---

Report on the annual meeting

EFFECT OF AMINO ACID SOLUTION ON THE BLOOD AMMONIA LEVEL

We have carried out several basic experiments on artificial liver support and found that the plasma free amino acid balance was lost after treatment according to this procedure (2). Application of fluid therapy-Using conventional amino acid preparations available on the market- ls not adequate during and after the treatment with artificial liver. Fluid therapy using mainly special amino acid preparations should have been established ; preparations, named Todai Hospital fluid (THF) (3), are intended to correct the deranged aminogram, supply nutrition and promote the improvement in symptoms.
Furthermore, experimental animals with acute hepatic insufficiency of diverse severity were prepared (4),and basic experiments were performed wich these animals to see how the efficacy of THF developed. In the basic experiments, psychoneurotic symptoms and the electroencephalogram were improved with the lowering of the blood ammonia level.
Clinically, THF was not only used as a therapeutic agent after treatment by artificial liver support in patients with fulminant hepatitis, but is also served as a further indication in hepatic encephalopathy accompanying chronic liver diseases in late stages. Improvement in encephalopathy was observed immediately after the administration of THF and persisted while the aminogram pattern retumed to the premedication representation. There was more improvement in patients in whom ammonemia was complicated, and the blood ammonia level was reduced markedly.

---

---

To read the PDF file you will need Adobe Reader installed on your computer.