J.Jpn. Surg. Soc.
ISSN 1880-1129

[Abstract] [Full Text PDF] （in Japanese / 1598KB） [Members Only And Two Factor Auth.]

J.Jpn. Surg. Soc.. 86(9): 1177-1179, 1985

Report on the annual meeting

CHANGES OF PANCREATIC HORMONES IN PORTAL AND MORPHOLOGICAL CHANGES OF ISLET CELLES OF LANGERHANS AFTER HEPATECTOMY

Second Department of Surgery, Kinki University School of Medicine, Osaka, Japan

Takaaki Sudo, Ryuji Shobu, Kiichi Shono, Masao Kawamura, Hiroya Umemura, Takeshi Kuyama

Hybrid adult dogs weighing 12 to 15kg were laparotomized before, one week, and one month after partial hepatectomy : Pancreatic tissues were taken and examined by the PAP staining. Also, the animals were intravenously injected via peripheral veins with 50 percent glucose 0.5g/kg before, one week, and one month after surgery, and their portal blood was taken before, 5, 15, 30, 45 and 60 minutes after injection, and submitted to examinatin of insulin, glucagon, somatostatin and blood sugar levels. We obtained these results as follows.ΣIRI which represents an increment of insulin secretion after glucose loads, showed a decrease at one week after surgery (p＜0.05) and an increase at one month after surgery (p＜ 0.05). Somatastatin levels of portal blood showed marked increase after surgery (p＜0.05).
Observation on the area of Langerhans islets revealed approximately 4.6 fold hypertrophy from the size of 486±23μmm2 before surgery to 2236±98μmm2 one month after surgery (p＜0.05). Insulin secreting B cells were found to contain increased secreting granules.
Somatostatin secreting D cells increased 2.8-fold in number one month after surgery, showing mitotic figures.

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