J.Jpn. Surg. Soc.. 86(9): 1116-1119, 1985
Report on the annual meeting
THE ROLE OF BODILY DEFENSE AGAINST TUMOR BY REGIONAL LYMPH NODES
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Department of Surgery, Tokyo Women’s Medical College Daini Hospital, Tokyo, Japan Noburu Sakakibara, Kenji Ogawa, Hirokazu Yagawa, Yoichi Ohtani, Hirokazu Kawata |
Anti-tumor immune response was observed in regional lymph nodes in the tumor-bearing mouse. Advance of tumor or distance between lymph nodes and tumor effected the strength of the immune responses.
In clinical study, anti-tumor immune response was observed similarly on draining lymph nodes of gastric cancer or colo-rectal cancer by measuring the PHA lymphocyte blastgenesis formation, the natural killer activity and the T-cell subpopulation. The response of regional lymph nodes was suppressed in early stage cases, while that of remote nodes was preserved comparatively.
As is stated above, anti-tumor immune response was confirmed in draining lymph nodes. This suggested that at least for early gastric cancer without lymph node metastasis, surgical treatment with limited lymph node dissection should be considered in order to preserve bodily defense mechanism of regional lymph nodes.
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