J.Jpn. Surg. Soc.. 86(9): 1108-1111, 1985

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Report on the annual meeting

CLINICAL AND EXPERIMENTAL STUDY OF THE HOST DEFENSE MECHANISM FROM THE ASPECT OF TUMOR IMMUNOLOGY

The host defense mechanism was fundamentally and clinically investigated from the aspect of tumor immunology. The behavior of macrophages in the immune systems of experimental animals demonstrated different patterns of response in the bone marrow, peritoneal cavity and spleen, respectively. It was doubtless that the spleen occasionally exerted an immunosuppressive action.
Ectopic immunization of syngeneic rats with normal liver cells resulted in specific inhibition of the growth of the tumor cells (AH-130) derived from liver. This seemed to strongly suggest a local immune response. In clinical cases, the host defense mechanism was found to collapse due to surgical intervention, malnutrition and immunosuppressive substances.
The relation between complements and host defense mechanism has been controversial. Our studies indicated the serum complement level to be the most reliable parameter for understanding the host defense mechanism.
Since the combination of immunostimulants and anticancer drugs is likely to induce anticancer drugs to exert an adverse effect depending on the time of such combination, timing of combined administration of drugs should be chosen with great care.

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