J.Jpn. Surg. Soc.
ISSN 1880-1129

[Abstract] [Full Text PDF] （in Japanese / 2761KB） [Members Only And Two Factor Auth.]

J.Jpn. Surg. Soc.. 85(12): 1528-1536, 1984

Original article

CLINICAL STUDIES ON RELATION OF NONSPECIFIC IMMUNOLOGICAL PARAMETERS TO OPERATIVE RADICALITY AND PROGNOSIS IN GASTRIC CANCER PATIENTS

Second Department of Surgery, Gifu University School of Medicine, Gifu, Japan
*) Department of Surgery, Gifu Municipal Hospital, Gifu, Japan

Tomoharu Takekoshi, Shigetoyo Saji, Tsuneo Kida, Takao Umemoto, Kiichi Miya, Hiroo Oshita, Yukio Yokoyama, Satoru Yamamoto, Hiromi Tanemura, Tokuro Kunieda, Kazuki Sakata, Atsushi Misao*), Takao Ito*), Sengai Tanaka*)

Ratio of IgG Fc receptor positive T (Fc R(+) T) cell, PHA-induced lymphoblastogenesis and serum α2-globulin ratio were examined in 90 preoperative cases with gastric cancer and were analyzed according to various stages of cancer and compared with normal controls. Moreover, on the basis of correlations among these parameters, operative radicality and prognosis were discussed.
Fc R(+) T cell ratio was significantly elevated. PHA-lymphoblastogenesis was significantly reduced. α2-globulin ratio tended to increase as the stage progressed. A significant negative correlation was found between Fc R(+) T cell ratio and PHA-lymphoblastogenesis. In a scattergram indicating this correlation, the group of noncurative resection or exploratory laparotomy was divided into two areas, B1 and B2. The group of curative resection (A1) was located between B1 and B2, and the normal control group was located in the area common to B1 and A1, Cases succumbing to cancer within one year postoperatively were found to accumulate either in the area B2 or in the area B1 minus the araea common with A1. No significant correlation was found between Fc R(+) T cell ratio and α2 -globulin ratio. However in a scatter gram, the almost same relationship between these three groups was noted.
Thus it has suggested that postoperative prognosis (at least for two years) is good in cases which an immunological harmony among these parameters is maintained preoperatively.

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