J.Jpn. Surg. Soc.. 85(10): 1274-1287, 1984

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Original article

EFFECT OF VAGOTOMY ON GASTRIC WALL AUTONOMIC RESPONSES, MUCOSAL CHOLINESTERASE ACTIVITY AND GASTRIC ACID SECRETION IN CATS

Adrenergic and cholinergic innervation of the stomach was investigated using histochemical techniques, and gastric mucosal cholinesterase (ChE) activity was measured by a calorimetric method. The effects of vagal nerve stimulation on gastric mucosal ChE activity was examined, and the following results were obtained.
1. No differences in innervation and mucosal ChE activity were found between the lesser and greater curvatures of the stomach.
2. High ChE activity and a wide and dense network of cholinergic nerve fibers were observed in the fundic mucosa, but in the antral mucosa the fibers were limited and ChE activity was low.
3. The number of cholinergic fibers was markedly reduced in the intermediate zone.
4. Mucosal ChE activity increased temporarily after truncal vagotomy, but after 6 months it returned to the original value.
5. Antral mucosal ChE activity became elevated temporarily after vagal stimulation, but decreased rapidly thereafter.
6. Denervation of hepatic, celiac and antral branches of the vagus caused as ignificant decrease in acid secretion. This suggests that these nerves are also involved in gastric secretion, and that the vagal nerve fibers are distributed to the greater curvature of stomach via these branches.

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