J.Jpn. Surg. Soc.. 85(9): 1147-1150, 1984
Report on the annual meeting
INTRA-ARTERIAL INFUSION CHEMOTHERAPY FOR CANCERS OF LIVER, BILIARY TRACT AND PANCREAS WITH OR WITHOUT HYPERTHERMIA
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Department of Surgery, Hanzomon Hospital, Tokyo, Japan Tsuyoshi Miura |
Approximately 60% of the patients with primary hepatic cancer showed objective response to the intra-arterial infusion of 5-FU and MMC. However, many patients developed hemorrhage of esophageal varices, gastroduodenal ulcers, jaundice and ascites because of high incidence of hepatic cirrhosis with hepatoma. Fifty percent survival period was only 5.2 months and 26% of the patients so treated survived a year or longer.
Metastatic liver cancers, on the contrary, showed better results as compared to those of the primary liver cancer. Fifty percent survival period for metastatic liver cancer was 8.0 month and 42 percent of the patients survived a year or longer.
For the cancer of head of the pancreas, the combination of intra-arterial infusion chemotherapy and microwave local hyperthermia was proved to be the most effective way to control cancer. Nine patients before 1975 were treated with intra-arterial infusion chemotherapy alone and 25 patients in and after 1975 were treated by intra-arterial infusion chemotherapy in combination with hyperthermia. In the first group the average survival of 4.2 month was attained whereas 9 month average survival was seen in the combination therapy group. With this combination therapy 17 of 25 patients (68%) survived more than 6 month and 36% of the patients survived more than one year. The longest survival was 7 years. This study confirms hyperthermia potentiated the effect of intra-arterial infusion chemotherapy.
During the past 18 years, 5-FU and MMC were administered by intra-arterial infusion to 729 patients with advanced cancers of the liver, biliary tract and pancreas. The intra-arterial infusion chemotherapy seems to offer exciting new avenue of approach to the management of cancer.
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