J.Jpn. Surg. Soc.
ISSN 1880-1129

[Abstract] [Full Text PDF] （in Japanese / 2027KB） [Members Only And Two Factor Auth.]

J.Jpn. Surg. Soc.. 85(9): 961-964, 1984

Report on the annual meeting

NUTRITIONAL SUPPORT IN SURGERY: WITH SPECIAL REFERENCE TO FAT EMULSION AND CARNITINE

Third Department of Surgery, Faculty of Medicine, Tokyo Univernity, Tokyo, Japan

Mitsuru Yamakawa, Jun Maeda, Kuniaki Kojima, Yushin Tsai, Toyoki Fujita, Katsuyoshi Sugisaki, Kenhiko Momose, Kiyokazu Furuya, Yoshio Kondo

Energy metabolism of fat emulsion has been studied in rats with various conditions including postoperative catabolism, chronic and acute hepatic dysfunction, diabetes and sepsis. The results indicate that fat emulsion is rapidly eliminated from the blood stream and metabolized readily even in such conditions. Based on these findings, we have actively employed fat emulsion clinically as energy source.
In septic rats, it was demonstrated that levels of carnitine decreased and that this decrease was based upon a decrease of synthesis. When carnitine was administrated together with fat emulsion, the energy metabolism returned to approximately normal level.
This report also describes the tissue concentrations of carnitine in diabetic rats and the blood and urine concentrations of carnitine in postoperative patients.

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