J.Jpn. Surg. Soc.. 85(1): 29-37, 1984
Original article
EXPERIMENTAL MINUTE GASTRIC CANCER INDUCED BY N-ETHYL-N'-NITRO-N-NITROSOGUANIDINE IN DOGS
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The First Department of Surgery, University of Kagoshima, Kagoshima, Japan Hidehiro Nomura, Mitsumasa Nishi, Takae Kawaji, Sonshin Takao, Yoichi Kaneko, Shiro Yamamoto, Shunichiro Omodaka, Tisaka Okubo, Ryuichi Agune |
As a result of the administration, we found development of minutecancer as follows :
1. In 3 animals, male beagle killed at 575th day, male mongrel at 1,105th days and male mongrel at 1,245th days, a total of 20 neoplasms of the stomach was found (18 early cancers and 2 advanced cancers). 13 of which being the minutecancer measuring less than 0.5 cm. There were 11 mucosal cancers and 2 submucosal cancers.
2. When classified by the macroscopic pathological type, none was classified as the elevated type (I, Ila types), 5 lesions as the flat type (Ilb type), and 8 lesions as the depression type (Ilc type). Two lesions of submucosal cancer belonged to Ilc type.
3. When classified by the histological type, 2 were classified as papillary adenocarcinoma, 2 as well differentiated tubular adenocarcinoma, 1 as moderately differentiated tubular adenocarcinoma, 5 as poorly differentiated adnocarcinoma and 3 as signet-ring cell carcinoma.
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