J.Jpn. Surg. Soc.
ISSN 1880-1129

[Abstract] [Full Text PDF] （in Japanese / 4560KB） [Members Only And Two Factor Auth.]

J.Jpn. Surg. Soc.. 84(12): 1243-1250, 1983

Original article

RENAL FUNCTION AFTER ANESTHESIA AND ABDOMINAL SURGERY A Comparative Study between Halothane and Epidural Anesthesi

*) Second Department of Surgery and Department of Anesthesiology, Nagoya University, Nagoya, Japan
**) School of Medicine, Nagoya University, Nagoya, Japan

Fumihiko Yasuma*), Jun Akune*), Shigeru Hirose*), Tatsuhei Kondoh*), Yoshimichi Namba**)

β2-microglobulin(BMG) and osmolarity (OSM) in the plasma and in the urine were measured in 23adult female patients before and after abdominal surgery. Creatinine clearance (Ccr) and free water clearance (C-H2O) were determined simultaneously. These patients were divided into two groups, the first group receiving halothane anesthesia (n=l4) and the second group undergoing epidrual anesthesia (n=9). Results were summarised as follows.
1. Ccr temporarily increased in both groups on the day of operation (0-POD) and on the 1st postoperative day (1-POD), suggesting a physiological compensation to the increased metabolic and circulatory needs in the post-operative state.
2. Urinary BMG (U-BMG) concentration remarkably increased in both groups after the operation but the plasma BMG levels were unchanged. U-BMG returned to the pre-operative levels on the 4-POD in the 1st group and on the 2-POD in the 2nd group. Tubular dysfunction after anesthesia and surgery is believed to be responsible for this marked rise in U-BMG. The earlier recovery of U-BMG to the preoperative levels in the 2nd group indicates that the tubular dysfunction in epidural anesthesia is probably less in halothane anesthesia.
3. The results of C-H2O and urine OSM studies also indicate the postoperative tubular dysfunction but these parameters may not be so sensitive as U-BMG.

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