J.Jpn. Surg. Soc.. 84(9): 974-977, 1983
Report on the annual meeting
ROLE OF THE SPLEEN ON TUMOR IMMUNITY
－With Special Reference of Anti-Tumor Immunity Induced by Solubilized and Purified Tumor-Associated Antigen－
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*) Department of Surgery, Kansai Medical University, Osaka, Japan Manabu Yamamura*), Yoshinori Hamada*), Munehisa Kogata*), Shoji Uetsuji*), Masahide Kobayashi*), Michinori Sakaguchi*), Masakatsu Yamamoto*), Masakazu Adachi**) |
The immunization with subcutaneous injections of PNA-binding glycoproteins at early phase following resection of primary footpad tumors of 3LL resulted in a significant decrease in incidence and size of lung metastases. The delayed immunization, however, failed to suppress the development and growth of metastatic lung tumors after surgery. The suppression of postoperative development of lung metastases was found to depend on timing of immunization following local tumor resection.
Splenectomy performed simultaneously with amputation of tumor-bearing leg was completely abolished the decrease in the development and growth of postoperative lung metastases in immunizedmice.
Evidence of lymphoid system involvement in the control of metastatic tumor growth was also supported by the observation of in vivo tumor neurtalization assay utilizing the spleen cells.
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