J.Jpn. Surg. Soc.. 84(9): 800-803, 1983
Report on the annual meeting
HETEROGENEITY IN DRUG SENSITIVITY OF HUMAN TUMORS IN THE HUMAN TUMOR COLONY-FORMING ASSAY
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*) The 2nd Department of Surgery, Fukui Medical College, Fukui, Japan Nobuhiko Tanigawa*), Yoshifumi Mizuno**), Kazuo Honda**), Takayuki Hashimura***), Kisaku Satomura**), Yorinori Hikasa**) |
The results indicate that the reported discrepancies of in vitro and in vivo results in clinical trials with TCFA for predicting of resistance or sensitivity to cytosatic drugs may be due to therapeutic heterogeneity among tumor colony-forming units within a primary tumors and between primary tumor and metastases, and that the results from a metastatic lesion may have more profound implications in planning treatment of other metastatic lesions of the same patient.
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