J.Jpn. Surg. Soc.. 84(9): 762-766, 1983

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Report on the annual meeting

BIOLOGICAL CHARACTERISTICS AND THE SURGICAL INDICATIONS IN ORGAN METASTASIS OF ESOPHAGEAL CANCER PATIENTS UNDERGOING CURATIVE OPERATION PREVIOUSLY

Indications of surgical therapy for esophageal cancer patients with metastasis are limited. The reasons are as follows: patients undergoing radical surgery can not tolerate further surgery for metastatic tumors which ordinarily appear in major organs within two years (85% of cases) after the first surgery. Moreover, such tumors are originally malignant and no satisfactory results have been obtained by use of surgical procedures. One patient survived 11 years after such surgery for brain metastasis which occurred one year after the first operation for carcinoma of the thoracic esophagus. The few cases which may possibly benefit from surgical treatment for metastatic tumors are indicated by the DNA histogram patterns, degrees of vascular invasion and round cell infiltration of the tumor tissues in the primary lesions, and the grade of sinus histocytosis in regional nodes. The vascular structure of human esophageal cancers transplantable to nude mice is variable and shows sinusoid like pattern.
The diameters of cells of human esophageal cell lines range from 14 to 23μ and are larger than the caliber of the capillary. Five of 9 cell lines have an effect on platelet aggregation, in contrast to normal cells which have no such effect. Seven of 9 cell lines show the dominant effect of procoagulant activity of cultured cells. The value of cAMP in cells is in reverse correlation to the sialic acid in those cells.

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