J.Jpn. Surg. Soc.
ISSN 1880-1129

[Abstract] [Full Text PDF] （in Japanese / 1939KB） [Members Only And Two Factor Auth.]

J.Jpn. Surg. Soc.. 84(9): 758-761, 1983

Report on the annual meeting

THE DIVERGENT HISTOLOGY IN THE PRIMARY AND METASTATIC LESIONS OF THE THYROID CARCINOMA

1) Division of Endocrine Surgery, Kawasaki Medical School, Kurashiki, Japan
2) Ito Hospital, Tokyo, Japan
3) Department of Pathology, School of Medicine, Keio University, Tokyo, Japan
4) Department of Pathology, Kawasaki Medical School, Kurashiki, Japan

Tanekazu Harada1), Takashi Mimura2), Kunihiko Ito2), Yuri Nakanishi1), Tsuneaki Senoo1), Yasuhiro Hosoda3), Kazuhiro Yakumaru3), Chotatsu Tsukayama4)

The metastatic lesions of malignant diseases tend to present similar histological findings as the primary tumor. However, thyroid carcinoma is one of the malignancies which may be an exception to this rule. We have reviewed 61 consecutive autopsies of thyroid cancer patients at the Ito Hospital and Kawasaki Medical School Hospital during a period between 1969-1982.
Fity-ftve of 61 cases of thyroid carcinoma were found to have metastatic spreads beyond the thyroid. The uniform pathological fmdings were present in 5 of 9 papillary adenocarcinomas, 14 of 15 anaplastic carcinomas, and 1 of two squamous cell carcinoma and one epidermoid carcinoma. The remaining 36 patients were found to have different histological fmdings in metastatic lesions from the primary tumor. The histological types in coexisting metastases varied from one lesion to the other ; the primary tumor was adenocarcinoma, but one of the metastases was anaplastic and the others showed adenocarcinoma or its combination. Those histological divergence in the primary tumor and metastases can be considered as the results of anaplastic or squamous cell transformation from adenocarcinoma. Such alteration of the histological findings in thyroid carcinoma calls for the reassessment of the therapeutic strategy.

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