J.Jpn. Surg. Soc.. 84(7): 602-611, 1983

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Original article

PATHOGENESIS OF ENDOGENOUS ENDOTOXEMIA IN CHRONIC LIVER DISEASE
－With Special Reference to the Experimental Fatty Liver in Germfree Animals－

The effect of intestinal bacterial flora and endotoxin on fatty liver with germfree (GF) and conventional (CV) rat in the 12th and 24th week was investigated after giving fatty diet which was added 1% cholesterol-0.5% cholic acid to the basic diet.
Results are as follows.
1) Serum biochemistry
Serum GOT, GPT, ALP and cholesterol values increased after giving the fatty diet in both groups.
2) Limulus Gelation Test
In CV group, endotoxin was detected in 2 of 10 cases in portal blood and was completely absent in arterial blood. After the fatty diet, endotoxin increased gradually both in portal and arterial blood.
3) Cyclic AMP values on glucagon challenge (P/B ratio)
In both groups, the levels of the P/B ratio maintained low values compared with control. In CV group, the values were lower in endotoxin positive cases than negative ones.
4) Hepatic carbohydrate metabolism
Abnormal hepatic F6P, glucose, FDP and PEP values were observed in CV group and reduction of the levels of hepatic F6P, G6P and glucose values were remarkable in GF group. Hepatic G6P in CV group and FDP in GF group remained unchanged. Impairment of F6P and G6P in CV group, was significant in endotoxin positive cases than in negative ones.

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