J.Jpn. Surg. Soc.. 83(12): 1417-1428, 1982
Original article
ACUTE OBSTRUCTIVE SUPPURATIVE CHOLANGITIS: AN EXPERIMENTAL STUDY WITH REFERENCE TO HEMODYNAMICAL AND BIOCHEMICAL ASPECTS OF THE LIVER AND KIDNEY
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The Second Department of Surgery, Kagoshima University School of Medicine (Director: Prof. Akira Taira) Tsutomu Furukawa |
Group I(n = 8):Ligature of the common bile duct (LCBD) with saline infusion into the duct.
Group II(n = 12):LCBD with endotoxin into the duct.
Group III(n = 18):LCBD for two weeks and endotoxin into the duct.
Group IV(n=6):LCBD with endotoxin into the vein.
Group V(n=5):LCBD for two weeks and endotoxin into the vein.
Endotoxin produced hypodynamic shock by either route of administration. Portal pressure was initially elevated and later was depressed. Portal flow was altered in relation to these pressure changes. Compensatory flow changes between the portal vein and hepatic artery were observed with the exception of Groups III and V. These phenomena are concerned with hepato-renal syndrome.
The liver function was deteriorated by either route of endotoxin administration, with ductal administration producing greater alteration. Saline reflux per se also produced liver cell damage.
Serotonin of thrombocyte origin increased markedly, indicating a possible cause of hepato-renal dysfunction accompanying vasoconstriction.
Increase in plasma alanine probably due to disturbances of alanine cycle and gluconeogenesis by endotoxin were observed.
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