J.Jpn. Surg. Soc.. 83(12): 1411-1416, 1982

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Original article

POSTOPERATIVE PATHOPHYSIOLOGY OF CROHN’S DISEASE
－With Special Reference to Early Diagnosis of the Recurrence－

Ten patient‘s with Crohn's disease operated on in our department were investigated mainly by means of blood sampling before operation and at the time of follow-up. These patients were divided into two groups:Six were non-recurrence group and four were recurrence group. From these investigations the following results were obtained with regard to postoperative pathophysiology as well as early diagnosis of the recurrence. In recurrence group, serum hemoglobin (Hb), serum iron (Fe), serum calcium (Ca), and gain of weight were lower than those of non-recurrence group which showed within normal limits at the time of follow-up. However, erythrocyte sedimentation ratio (ESR), CRP, IgG, IgA and IAP were higher than normal level only in the recurrence group. The following results were obtained.
1) In non-recurrence group, postoperative general condition was as good as that of healthy subjects. So, for cases in which the occurrence of short bowel syndrome can be avoided, the operation is recommended for the treatment of Crohn‘s disease.
2) For early diagnosis of the recurrence, levels of Hb, Fe, Ca, ESR and CRP are considered very valuable.
3) In recurrence group, immunological condition is not normal, and levels of IgG, IgA and IAP may be available for early diagnosis of the recurrence.

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