J.Jpn. Surg. Soc.. 83(12): 1387-1397, 1982

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Original article

EXPERIMENTAL STUDIES ON THE ETIOLOGY OF STRESS ULCER WITH SPECIAL REFERENCE TO AGING

In order to elucidate the relation between etiology of stress ulcer and aging, the authors inflicted restrained and water-immersion stress on both young and aging rats, and measured ulcer index, gastric acidity, plasma corticosterone, amine contents in the brain and the gastric mucosa, gastric blood flow and mucopolysaccharides in the gastric mucosa.
After stress loading, remarkable ulcer was recognized earlier in the aging rat group than the young rat group. Before stress loading, the blood flow in the aging group was decrease in rate to about 79％ of that in the young group, and mucopolysaccharides contents were also lower than in the young group. After stress loading, the blood flow in the aging group was less at an early stage than in the young group, and the mucopolysaccharides contents showed also remarkable decrease.
Noradrenalin and serotonin contents decreased earlier and more remarkably in the aging group than in the young group. These contents thereafter remained unchanged. On the other hand, gastric acidity and plasma corticosterone contents were increased as adequate response after stress loading in the both groups.
These results suggest that remarkable stress ulcer in the aging group may be due to weakness of tissue resistance of the stomach, decrease of the blood flow and parasympathetic dominant state after stress loading.

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