J.Jpn. Surg. Soc.
ISSN 1880-1129

[Abstract] [Full Text PDF] （in Japanese / 767KB） [Members Only And Two Factor Auth.]

J.Jpn. Surg. Soc.. 83(12): 1359-1368, 1982

Original article

INFLUENCE OF OPERATIVE STRESS ON CANCER BEARERS AND EFFECT OF IMMUNOPOTENTIATORS. EXPERIMENTAL AND CLINICAL STUDIES

1) 2nd Department of Surgery, Gifu University School of Medicine
2) Department of Surgery of Gifu City Hospital

Hiromi Tanemura1), Tomoharu Takekoshi1), Satoru Yamamoto1), Atsushi Misao2), Shigetoyo Saji1), Takao Ito2), Sengai Tanaka2), Tokuro Kunieda1), Kazuki Sakata1)

Subcutaneous inoculation of the metastasizing rat's mammary tumor (MRMT-1) was done at the unilateral dorsal flank of syngeneic female Sprague-Dawley rats. Two weeks later surgical tumor excision was done in one group and surgical tumor excision plus laparotomy for 30 min. were done in another group. Each group consisted of 3 subgroups:The one treated by preoperative immunotherapy with OK-432, the one treated by postoperative OK-432 therapy and the one without immunotherapy. In the laparotomy group without immunotherapy, PHA-lymphoblastogenesis was reduced postoperatively and incidence of lung metastasis was increased. In the laparotomy group with preoperative immunotherapy neither postoperative reduction in lymphoblastogenesis nor increase in lung metastasis was observed, just like in the group of simple tumor excision.
Cases of gastric and colorectal cancers, 71 cases in all, were divided into 3 groups:The one receiving pre-and postoperative immunotherapy with OK-432 plus PSK, the one receiving postoperative immunotherapy and the one without immunotherapy. In the last group PHA-lymphoblastogenesis was reduced at 1 and 2 week (s) postoperatively, while in the first group no such reduction in lymphoblastogenesis was observed. In 12 cases of mammary cancer, in which no immunotherapy was done, no postoperative reduction in lymphoblastogenesis was seen.

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