J.Jpn. Surg. Soc.. 83(11): 1295-1306, 1982

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Original article

INTRA-ARTERIAL INFUSION TREATMENT FOR PATIENTS WITH MALIGNANT HEPATIC TUMOR
－WITH SPECIAL REFERENCE TO HEPATIC PHARMACOKINETICS AND TO COMBINED USE OF VASOACTIVE AND ANTITUMOR DRUGS－

Fundamental and clinical studies on intra-arterial infusion chemotherapy combined with a vasoactive drug are presented in this paper. For the purpose of obtaining higher drug levels in hepatic tumor than in normal hepatic tissue, five vasoactive drugs were tested for their in vivo effects on the distribution of hepatic blood flow and antitumor drugs to normal and malignant hepatic tissues. Of the 5 drugs, angiotensin II and prostaglandin E₁ enhanced intrahepatic tumor blood flow by 15 to 30％, while the other agents decreased it by 30 to 70％. Moreover, angiotensin II and dopamine augmented hepatic I tumor concentrations of adriamycin (p＜0.01 and p＜0.02, respectively). Best result was obtained from the experimental group treated with combined use of angiotensin II and adriamycin. On the basis of these data obtained, joint use of angiotensin II and antitumor drugs in intrahepatic arterial infusion has been performed for 10 patients with malignant hepatic tumor. Of the 10 patients 5 had partial response and 1 had minor response. Furthermore, one gastric cancer patient with hepatic metastases, who underwent surgical removal of the primary foci, had complete tumor regression in hepatic involvement. The remaining 3 patients, who had unresectable primary foci, were too far advanced to respond to these infusion treatments.

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