J.Jpn. Surg. Soc.. 83(9): 994-998, 1982
Report on the annual meeting
CELL MEDIATED IMMUNITY AND TF IMMUNOTHERAPY IN ADVANCED PRIMARY LUNG CANCER PATIENTS WITH RESECTION
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Department of Surgery, Institute of Pulmonary Cancer Research, Chiba University School of Medicine, Chiba, Japan Takehiko Fujisawa, Yutaka Yamaguchi, Hideki Kimura, Nobumasa Satoh, Masaaki Arita |
One hundred and thirty seven resected patients including 88 patients with postsurgicopathologic III and IV stages were randomized postoperatively. Sixty seven patients received TF plus chemotherapy and 70 patients received chemotherapy alone. One hundred and forty household contact family members were utilized for TF donors.
Cell mediated immunity in peripheral blood and regional lymph node was evaluated by mixed lymphocyte-autologous tumor cell reactivity (MLTR) and cell mediated cytotoxicity against autologous tumor cells.
The results obtained here are as follows:
1) Cell mediated immunity was not suppressed in patients with stage III disease, however, significantly suppressed in patients with stage IV disease, compared with that of patients with stage I disease.
2) MLTR in regional lymph node had close relation with tumor size.
3) There existed the potentiality of cytotoxic activity against autologous tumor cells in regional lymph node of lung cancers.
4) Among the patients with stage III disease,th e survival of TF group was significantly better than that of randomized controls, when the patients were treated with relative curative resection (p＜0.025, Cox-Mantel test). However, there was no significant difference between the two curves of TF and controls, when the patients were treated with noncurative resection.
5) The significant effect TF was observed among the patients with t3 disease (p＜0.005,Cox-Mantel test), however, there was no significant effect among the patients with n2 disease.
In conclusion, TF was beneficial for advanced primary, lung cancer patients with resection as postoperative adjuvant therapy.
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