J.Jpn. Surg. Soc.. 83(9): 912-915, 1982

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Report on the annual meeting

MANAGEMENT OF ADVANCED CHILDHOOD CANCER; EXPERIENCE IN TREATING WILMS' TUMOR, GERM CELL TUMORS AND NEUROBLASTOMA

Surgical data derived from the 11 survivors of Stage III or IV diseases including Wilms' tumor, germ cell tumors and neuroblastoma were analyzed to evalute the effects of the multimodal therapy used at our institution.
In the treatment of 29 children with Wilms' tumor, lung metastases appeared postoperatively in three patients, and hepatic involvements, occurred preoperatively in two, were successfully treated with intensive chemotherapy consisting of actinomycin-D, vincristine, cyclophosphamide and adriamycin, in addition to radiation used locally. These four patients are alive more than five years without reccurrence.
There were three long-term survivors from advanced germ cell tumors. The tumors were Stage III testicular and presacral yolk sac tumors and Stage IV dysgerminoma, treated with repeated surgery, intensive chemotherapy and sufficient irradiation. In these tumors, studies of tumor markers such as alpha-fetoprotein and beta-submit HCG were greatly useful in the follow-up.
Certain aspects concerning the prognosis of neuroblastoma will be amended with the progress of multi-modal therapy based on experimental cell cycle analyses of neuroblastoma.

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